HCG 10000iu

What is HCG 10000iu?

Human Chorionic Gonadotropin (HCG) is a naturally occurring placental glycoprotein hormone that binds to and activates the luteinizing hormone/choriogonadotropin receptor (LHCGR). It is structurally similar to luteinizing hormone (LH), but contains unique features that prolong its half-life and biochemical activity.

In research environments, HCG is widely used to study:

• Luteinizing hormone receptor signaling

• Reproductive endocrinology

• Steroidogenesis

• Paracrine communication

• Angiogenesis and cellular development

This product is intended for laboratory and scientific research use only.

Chemical Structure of HCG 10000iu

HCG is a heterodimeric glycoprotein hormone, approximately 37.9 kDa, composed of two subunits:

• Alpha (α) Subunit – 92 amino acids

Shared with LH, FSH, and TSH.
Contains two N-linked glycosylation sites.

• Beta (β) Subunit – 145 amino acids

Unique to HCG.
Includes an extended C-terminal peptide (CTP) of 24 amino acids, responsible for increasing its half-life.
Contains two N-linked and four O-linked glycosylation sites.

Key Structural Features

• ~30% carbohydrate content — improves stability and biological persistence

• Eight total sugar chains

• Cystine-knot motif with three disulfide bonds per subunit, providing structural rigidity essential for receptor binding

This complex structural arrangement gives HCG high receptor affinity and long-lasting signaling capability.

What Are the Effects of HCG 10000iu?

Preclinical and in-vitro research demonstrates that HCG participates in several biological pathways:

• LHCGR-Mediated Signaling

• Activates Gs and Gq protein pathways

• Stimulates cAMP production

• Promotes steroidogenesis in gonadotrophin-responsive cells

• Angiogenic & Paracrine Activity

• Induces endothelial cells to release VEGF and other angiogenic factors

• Supports tissue vascularization in experimental models

• Reproductive Endocrine Modulation

• Enhances progesterone secretion

• Supports oocyte maturation

• Aids in early embryonic development (in research contexts)

• Biased Agonism

HCG produces unique signaling kinetics compared to LH:

• More sustained cAMP responses

• Distinct gene-expression patterns

• Longer duration of receptor activation

These characteristics make HCG a valuable tool for studying differential LHCGR signaling.

Research-Use Disclaimer

HCG 10,000 IU is supplied strictly for laboratory, educational, and scientific research purposes.
It is not intended for human or veterinary administration.