IGF-1 LR3 1MG

What is IGF-1 LR3 1MG?

IGF-1 LR3 (Insulin-like Growth Factor-1 Long Arginine 3) is a recombinant analogue of human IGF-1, modified to enhance stability and bioavailability. It differs from native IGF-1 by substitution of an arginine for glutamic acid at position 3 and the addition of 13 amino acids to the N-terminus. These changes reduce binding to IGF-binding proteins, extending its half-life and enabling prolonged biological activity. IGF-1 LR3 functions as a potent growth-factor agonist, influencing cellular proliferation, differentiation, and repair in laboratory settings.

Chemical Structure of IGF-1 LR3 1MG

• Sequence: MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA

• Molecular Formula: C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉

• Molecular Weight: ≈ 9117.5 Da

• CAS Number: 946870-92-4
  This engineered peptide shares tertiary similarity to endogenous IGF-1 but exhibits markedly reduced affinity for serum IGF-binding proteins, resulting in a plasma persistence approximately 120 times longer than native IGF-1.

What Are the Effects of IGF-1 LR3 1MG?

• Cellular Proliferation: Stimulates mitogenesis and differentiation in muscle, bone, and connective tissue models; promotes cell division in hepatic, renal, neural, and epithelial systems.

• Metabolic Regulation: Interacts with both IGF-1 and insulin receptors, enhancing glucose uptake and influencing lipid metabolism in preclinical studies.

• Myostatin Modulation: Evidence from murine and in-vitro models suggests IGF-1 LR3 attenuates myostatin signaling, supporting muscle regeneration and protecting myoblasts from apoptosis.

• Tissue Repair and Longevity Research: Investigated for its role in supporting tissue maintenance and repair, and in delaying cellular senescence in mammalian aging studies.

• Glucocorticoid Interaction: Experimental data indicate potential mitigation of glucocorticoid-induced muscle wasting in research models.

Research-Use Disclaimer:

IGF-1 LR3 is supplied strictly for laboratory and research purposes only. It is not approved for human or veterinary use. All biological effects described above are derived from preclinical or in-vitro data and should not be interpreted as clinical outcomes.