Kisspeptin-10

What is Kisspeptin-10?

Kisspeptin-10 (KP-10) is the shortest biologically active fragment of the kisspeptin peptide family, derived from the KISS1 gene. It is a potent endogenous ligand for the KISS1R (GPR54) receptor, which plays a central role in reproductive health, neuroendocrine signaling, and hormonal regulation. By stimulating the release of gonadotropin-releasing hormone (GnRH), Kisspeptin 10 influences luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion, which in turn regulate testosterone production, fertility, and reproductive function.

Beyond reproduction, Kisspeptin 10 has been investigated for its effects on sexual arousal, metabolism, appetite control, cancer biology, and cardiovascular health, making it a valuable peptide in diverse research applications.

Chemical Structure of Kisspeptin-10

• Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂

• Molecular Formula: C₆₃H₈₃N₁₇O₁₄

• Molecular Weight: ~1302.4 g/mol

• CAS Number: 374675-21-5

• PubChem CID: 25240297

• Synonyms: Kisspeptin-10, KP-10, Kisspeptin-10 (human), Metastin (45-54)

What Are the Effects of Kisspeptin-10?

Reproductive Health & Testosterone Regulation

• Stimulates GnRH release → increases LH & FSH secretion.

• Enhances testosterone production in males.

• Studied for potential applications in infertility and hypogonadism research.

Sexual Arousal & Motivation

• In animal studies, increased sexual activity, copulation frequency, and reduced rest periods.

• In human trials, improved sexual brain responses and penile tumescence during erotic stimuli.

• Shows potential in addressing hypoactive sexual desire disorder (HSDD).

Cancer Research

• Exhibits anti-metastatic effects in several cancers, including cervical, colon, lung, and brain cancers.

• KP-10 analogs have shown inhibition of cancer cell proliferation and migration via kinase pathway modulation.

Cardiovascular Research

• Regulates mTOR and AKT pathways, suggesting roles in oxidative stress reduction.

• Increases collagen content in myocardium, potentially influencing heart disease progression.

• Reduced kisspeptin levels have been linked to ischemic heart disease in humans.

Metabolism & Appetite Control

• Research indicates appetite suppression and energy expenditure regulation.

• Studied for potential roles in obesity and metabolic health.

⚠️ Legal Disclaimer & Safety Information

This compound is sold strictly for research purposes only. It is not approved for human use, therapeutic applications, or dietary supplementation. Handling should be performed only by qualified professionals with appropriate laboratory equipment.

Keep out of reach of children. Misuse may result in adverse effects.