SELANK

What is SELANK?

Selank is a synthetic heptapeptide (seven–amino–acid peptide) developed as an analogue of tuftsin, a naturally occurring immunomodulatory peptide. It is engineered for research in the fields of:

• Neuropsychology

• Anxiety and stress modulation

• Cognitive function

• Immune regulation

• Neuroprotection

Selank includes the core tuftsin sequence with an added Pro–Gly–Pro (PGP) tripeptide extension, which significantly increases its metabolic stability and duration of action in laboratory settings.

Selank is used exclusively for scientific and laboratory research and is not intended for human or veterinary use.

Chemical Structure of SELANK

Selank contains the amino acid sequence:

Thr–Lys–Pro–Arg–Pro–Gly–Pro (TKPRPGP)

Key structural characteristics:

• Molecular formula: C₃₃H₅₇N₁₁O₉

• Molecular weight: ~751.9 Da (PubChem CID: 11765600)

• Design: Tuftsin analogue with a C-terminal PGP extension

• Purpose: Enhanced resistance to enzymatic degradation

The PGP segment strengthens peptide stability, supports receptor interaction studies, and improves the molecule’s duration within experimental systems.

What Are the Effects of SELANK?

Scientific studies (preclinical and limited clinical research) have observed the following effects:

• Anxiolytic & Nootropic Activity

Research reports show:

• Reduced anxiety-like behavior in animal models

• Enhanced learning, memory, and cognitive performance

• No sedative or dependency effects (unlike benzodiazepines)

• GABAergic System Modulation

Selank influences gene expression related to:

• GABA(A) receptor pathways

• GABA-associated neurotransmission

• Neural inhibitory signaling involved in stress regulation

• Immunomodulatory Effects

Studies indicate:

• Decreased IL-6 (a pro-inflammatory cytokine)

• Normalization of Th1/Th2 immune balance

• Improved immune adaptation under stress

• Neuroprotective & Neuromodulatory Actions

Laboratory research shows:

• Increased BDNF (brain-derived neurotrophic factor) expression

• Regulation of serotonin and other monoamine levels

• Inhibition of enkephalin-degrading enzymes (supporting mood stability)

• Research in Stress, Alcohol Withdrawal & Ischemia

Models show potential research relevance for:

• Reduced anxiety-like symptoms during alcohol withdrawal

• Neuroprotection following ischemic injury

• Modulation of stress-response pathways

These findings apply only to controlled laboratory research and do not represent approved medical uses.

Research-Use Only Disclaimer

Selank is intended strictly for scientific, laboratory, and in vitro research.
It is not for human consumption, clinical use, or veterinary applications.
No dosing or medical guidance is provided.